Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), is associated with proteasomes and exerts a dual function in regulating protein degradation.USP14 protects protein substrates from degradation by removing ubiquitin chains from proteasome-bound substrates, whereas promotes protein degradation by activating the proteasome.Incre
Embodied material encounters and the ambiguous promise of biomedical futures: The case of biologically derived medicines
Therapies and prophylactics using biologically derived materials such as cells, microbes or tissues are often portrayed as key to increased future health.This article investigates the material preconditions of such visions.Building on feminist new materialist approaches, it explores the embodied material encounters between biologicals administered
Metaphor in product design
Addresses current research to the subject of metaphor as a field important in the design of industrial product, so it was a problem search: Does industrial product which is designed mainly to reflect the principle of metaphor role in receiving, and how the application of mechanisms theory correct as stipulated in institutions metaphor properly for
Exile encounters and cross-border mobility in early modern borderlands
The Ecclesiastical Province of Cambrai offers a highly interesting test case for both the field of borderlands studies and transregional history: since its erection in 1559 at the southern border of the Habsburg Low Countries, it hosted Catholic refugees from different regional backgrounds, such as the British Isles, France and Light Weight the ins
The Legitimacy of Constitutional Jurisdiction From Its Utility on a Democratic State : Three Key Issues
In a State ruled by democracy and the search for the effectiveness of fundamental rights, constitutional jurisdiction arises as an institution guaranteeing the effectiveness of the Constitution.However, when analyzing the constitutional adjudicative power Shirts placing it at the level of tensions between the powers and the democratic exercise of p