USP14: Structure, Function, and Target Inhibition

Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), is associated with proteasomes and exerts a dual function in regulating protein degradation.USP14 protects protein substrates from degradation by removing ubiquitin chains from proteasome-bound substrates, whereas promotes protein degradation by activating the proteasome.Incre

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Embodied material encounters and the ambiguous promise of biomedical futures: The case of biologically derived medicines

Therapies and prophylactics using biologically derived materials such as cells, microbes or tissues are often portrayed as key to increased future health.This article investigates the material preconditions of such visions.Building on feminist new materialist approaches, it explores the embodied material encounters between biologicals administered

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Metaphor in product design

Addresses current research to the subject of metaphor as a field important in the design of industrial product, so it was a problem search: Does industrial product which is designed mainly to reflect the principle of metaphor role in receiving, and how the application of mechanisms theory correct as stipulated in institutions metaphor properly for

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